Comprehensive HBOT Studies and Research
Delve into the newest developments in hyperbaric oxygen therapy (HBOT) with pioneering research and studies worldwide. Learn how hyperbaric oxygen chambers are revolutionizing wellness, recovery, and performance, providing clinics, wellness centers, and local practices with innovative tools to improve client results.
A Brief History of Hyperbaric Chambers
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1662: British clergyman Nathaniel Henshaw designed the first recorded hyperbaric chamber, called a "domicilium."
He believed pressure could treat respiratory diseases by controlling air pressure using bellows.
While crude, it introduced the idea of altering pressure to influence health.
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Mid-1800s: French surgeon G. Fontaine built the first multi-person hyperbaric chamber in 1877.
It was used to treat pulmonary conditions, nervous disorders, and more.
These chambers became popular in Europe for a short time, though the scientific basis was limited.
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diving and caisson work (e.g., bridge building) led to increased cases of decompression sickness (“the bends”).
Hyperbaric chambers were adapted to recompress divers and safely eliminate nitrogen bubbles from their bloodstream.
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Research into oxygen under pressure led to the formal development of Hyperbaric Oxygen Therapy (HBOT).
The U.S. Navy and medical researchers explored the therapeutic use of 100% oxygen at pressures above sea level.
Early uses included:
Gas gangrene
Carbon monoxide poisoning
Radiation injuries
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HBOT gained FDA approval for 13 specific conditions, including:
Non-healing diabetic wounds
Severe anemia
Crush injuries
Thermal burns
It also became popular in sports medicine, anti-aging, wellness, and off-label uses (e.g., Lyme disease, autism, traumatic brain injury).
SCIENTIFIC PAPERS
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Fife CE, Eckert KA, Carter MJ. "An update on the appropriate role for hyperbaric oxygen: indications and evidence." Plastic and Reconstructive Surgery. 2016;138(3 Suppl):107S–116S. doi:10.1097/PRS.0000000000002714.
Thom SR. "Oxidative stress is fundamental to hyperbaric oxygen therapy." Journal of Applied Physiology (1985). 2009;106(3):988–995. doi:10.1152/japplphysiol.91004.2008.
Link:https://journals.physiology.org/doi/full/10.1152/japplphysiol.91004.2008
Fujita N, Ono M, Tomioka T, et al. "Effects of hyperbaric oxygen at 1.25 atmospheres absolute with normal air on macrophage number and infiltration during rat skeletal muscle regeneration." PLoS One. 2014;9(12). Published 2014 Dec 22. doi:10.1371/journal.pone.0115685.
Link: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0115685
Vadas D, Kalichman L, Hadanny A, et al. "Hyperbaric oxygen environment can enhance brain activity and multitasking performance." Frontiers in Integrative Neuroscience. 2017;11:25. Published 2017 Sep 27. doi:10.3389/fnint.2017.00025.
Link: https://www.frontiersin.org/articles/10.3389/fnint.2017.00025/full
Hink J, Jansen E. "Are superoxide and/or hydrogen peroxide responsible for some of the beneficial effects of hyperbaric oxygen therapy?" Medical Hypotheses. 2001;57(6):764–769.
Link: https://www.sciencedirect.com/science/article/abs/pii/S0306987701914884
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Harch PG, Fogarty EF. "Hyperbaric oxygen therapy for Alzheimer’s dementia with positron emission tomography imaging: a case report." Medical Gas Research. 2019;8(4):181–184. Published 2019 Jan 9. doi:10.4103/2045-9912.248271.
Qiang L, Lan X, Su-qin X, et al. "Meta-Analysis on the Efficacy and Safety of Hyperbaric Oxygen as Adjunctive Therapy for Vascular Dementia." Frontiers in Aging Neuroscience. 2019;11:86. doi:10.3389/fnagi.2019.00086.
Link: https://www.frontiersin.org/articles/10.3389/fnagi.2019.00086/full
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Efrati S, Golan H, Bechor Y, et al. "Hyperbaric oxygen therapy can diminish fibromyalgia syndrome–prospective clinical trial." PLoS One. 2015;10(5). Published 2015 May 26. doi:10.1371/journal.pone.0127012.
Link: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0127012
Hadanny A, Bechor Y, Catalogna M, et al. "Hyperbaric oxygen therapy can induce neuroplasticity and significant clinical improvement in patients suffering from fibromyalgia with a history of childhood sexual abuse–randomized controlled trial." Frontiers in Psychology. 2018;9:2495. doi:10.3389/fpsyg.2018.02495.
Link: https://www.frontiersin.org/articles/10.3389/fpsyg.2018.02495/full
Efrati S, Hadanny A, Daphna-Tekoah S, et al. "Recovery of repressed memories in fibromyalgia patients managed with hyperbaric oxygen–case series presentation and suggested bio-psycho-social mechanism." Frontiers in Psychology. 2018;9:848. doi:10.3389/fpsyg.2018.00848.
Link: https://www.frontiersin.org/articles/10.3389/fpsyg.2018.00848/full
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Seymour et al. "Hyperbaric Oxygen Therapy Enhances Athletic Recovery Through Physiological Adaptations." Frontiers in Physiology. 2021;12:791872. doi:10.3389/fphys.2021.791872.Link: https://www.frontiersin.org/articles/10.3389/fphys.2021.791872/full
Shaw et al. "The Impact of Hyperbaric Oxygen Therapy on Athletic Performance and Recovery: A Comprehensive Review." Sports Medicine - Open. 2021;7(1):403. doi:10.1186/s40798-021-00403-w.
Link: https://sportsmedicine-open.springeropen.com/articles/10.1186/s40798-021-00403-w
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Rossignol DA, Bradstreet JJ, Van Dyke K, et al. "Hyperbaric oxygen in autism spectrum disorders." Medical Gas Research. 2012;2(1):16. doi:10.1186/2045-9912-2-16. Link: https://pubmed.ncbi.nlm.nih.gov/22703610/
Rossignol DA, Rossignol LW, Smith S, et al. "Hyperbaric for children with autism: a multicenter, randomized, double-blind, controlled trial." BMC Pediatrics. 2009;9:21. doi:10.1186/1471-2431-9-21.
Link: https://bmcpediatr.biomedcentral.com/articles/10.1186/1471-2431-9-21
Xiong T, Chen H, Luo R, et al. "Hyperbaric oxygen therapy for people with autism spectrum disorder (ASD)." Cochrane Database of Systematic Reviews. 2016;10. doi:10.1002/14651858.CD010922.pub2.
Link: https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD010922.pub2/full
Rossignol DA, Rossignol LW. "Hyperbaric oxygen therapy may improve symptoms in autistic children." Medical Hypotheses. 2006;67(2):216-228. doi:10.1016/j.mehy.2006.02.009.
Link: https://www.sciencedirect.com/science/article/abs/pii/S0306987706001198
Rossignol DA, Frye RE. "Evidence linking oxidative stress, mitochondrial dysfunction, and inflammation in the brain of individuals with autism." Frontiers in Physiology. 2014;5:150. doi:10.3389/fphys.2014.00150.
Link: https://www.frontiersin.org/articles/10.3389/fphys.2014.00150/full
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Çimşit M, Uzun G, Yıldız S. "Hyperbaric oxygen therapy as an anti-infective agent." Expert Review of Anti-infective Therapy. 2009;7(8):1015-1026. doi:10.1586/eri.09.76.
Link: https://www.tandfonline.com/doi/full/10.1586/eri.09.76
Ezra N, Dang K, Heuser G. "Improvement of attention span and reaction time with hyperbaric oxygen in patients with toxic injury due to mold exposure." European Journal of Clinical Microbiology & Infectious Diseases. 2011;30(1):1–6. doi:10.1007/s10096-010-0937-8.
Link: https://link.springer.com/article/10.1007/s10096-010-0937-8
Mader JT, Brown GL, Guckian JC, et al. "A mechanism for the amelioration by hyperbaric oxygen of experimental staphylococcal osteomyelitis in rabbits." Journal of Infectious Diseases. 1980;142(6):915-922 Link: https://pubmed.ncbi.nlm.nih.gov/7462700/
Delasotta LA, Hanflik A, Bicking G, et al. "Hyperbaric oxygen for osteomyelitis in a compromised host." Open Orthopaedics Journal. 2013;7:114–117. doi:10.2174/1874325001307010114.
Link: https://pmc.ncbi.nlm.nih.gov/articles/PMC3664446/?utm_source=chatgpt.com
Kolpen M, Lerche CJ, Kragh KN, et al. "Hyperbaric oxygen sensitizes anoxic pseudomonas aeruginosa biofilm to ciprofloxacin." Antimicrobial Agents and Chemotherapy. 2017;61(11). doi:10.1128/AAC.01024-17.
Link: https://journals.asm.org/doi/full/10.1128/AAC.01024-17
Gade PAV, Olsen TB, Jensen PØ, et al. "Modeling of ciprofloxacin killing enhanced by hyperbaric oxygen in Pseudomonas aeruginosa PAO1 biofilms." PLoS One. 2018;13(6). doi:10.1371/journal.pone.0198909.
Link: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0198909
Memar MY, Yekani M, Alizadeh N, et al. "Hyperbaric oxygen therapy: antimicrobial mechanisms and clinical application for infections." Biomedicine & Pharmacotherapy. 2019;109:440-447. doi:10.1016/j.biopha.2018.10.142.
Link: https://www.sciencedirect.com/science/article/pii/S0753332218354829
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Moen I, Stuhr LE. "Hyperbaric oxygen therapy and cancer: a review." Target Oncology. 2012;7(4):233–242. doi:10.1007/s11523-012-0233-x. Link: https://link.springer.com/article/10.1007/s11523-012-0233-x
Thom SR, Bhopale VM, Yang M. "Microparticle-induced vascular injury in mice following decompression is inhibited by hyperbaric oxygen: effects on microparticles and interleukin-1." Journal of Applied Physiology. 2019;126(4):1093–1100. Link: https://pubmed.ncbi.nlm.nih.gov/30763157/
Niezgoda JA, Serena TE, Carter MJ. "Outcomes of radiation injuries using hyperbaric oxygen therapy: an observational cohort study." Advances in Skin & Wound Care. 2016;29(1): Link: https://pubmed.ncbi.nlm.nih.gov/26650092/
Stepień K, Ostrowski RP, Matyja E. "Hyperbaric oxygen as an adjunctive therapy in the management of malignancies, including brain tumors." Medical Oncology. 2016;33(9):101. doi:10.1007/s12032-016-0814-0. Link: https://link.springer.com/article/10.1007/s12032-016-0814-0
Oscarsson N, Ny L, Mölne J, et al. "Hyperbaric oxygen reverses radiation-induced pro-fibrotic and oxidative stress responses in a rat model." Free Radical Biology and Medicine. 2017;103:248–255. doi:10.1016/j.freeradbiomed.2016.12.030. Link: https://www.sciencedirect.com/science/article/abs/pii/S0891584916311376?utm_source=chatgpt.com
Zembrzuska K, Ostrowski RP, Matyja E. "Hyperbaric oxygen increases glioma cell sensitivity to antitumor drugs with a novel isothiourea derivative in vitro." Oncology Reports. 2019;41(5):2703–2716. doi:10.3892/or.2019.7064.Link: https://www.spandidos-publications.com/10.3892/or.2019.7064
Lu QZ, Li X, Ouyang J, et al. "Further application of hyperbaric oxygen in prostate cancer." Medical Gas Research. 2019;8(4):167–171. Published 2019 Jan 9. doi:10.4103/2045-9912.248268. Link: https://pmc.ncbi.nlm.nih.gov/articles/PMC6352573/?utm_source=chatgpt.com
Choudhury R. "Hypoxia and hyperbaric oxygen therapy: a review." International Journal of General Medicine. 2018;11:431–442. Published 2018 Nov 20. doi:10.2147/IJGM.S172460. Link: https://pubmed.ncbi.nlm.nih.gov/30538529/
İyikesici M, Slocum A, Slocum A, et al. "Efficacy of metabolically supported chemotherapy combined with ketogenic diet, hyperthermia, and hyperbaric oxygen therapy for stage IV triple-negative breast cancer." Cureus. 2017;9(7). doi:10.7759/cureus.1445.Link: https://www.cureus.com/articles/7528-efficacy-of-metabolically-supported-chemotherapy-combined-with-ketogenic-diet-hyperthermia-and-hyperbaric-oxygen-therapy-for-stage-iv-triple-negative-breast-cancer#!/
Poff AM, Ari C, Seyfried TN, et al. "The ketogenic diet and hyperbaric oxygen therapy prolong survival in mice with systemic metastatic cancer." PLoS One. 2013;8(6). doi:10.1371/journal.pone.0065522.Link: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0065522
Seyfried TN, Mukherjee P. "The metabolic link between cancer and nutrition." Nutrition and Metabolism. 2005;2:30. doi:10.1186/1743-7075-2-30.Link: https://nutritionandmetabolism.biomedcentral.com/articles/10.1186/1743-7075-2-30
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Health Quality Ontario. "Hyperbaric oxygen therapy for the management of diabetic foot ulcers: a health technology assessment." Ontario Health Technology Assessment Series. 2017;17(5):1–142. Link: https://pmc.ncbi.nlm.nih.gov/articles/PMC5448854/
Bhutani S, Vishwanath G. "Hyperbaric oxygen and wound healing." Indian Journal of Plastic Surgery. 2012;45(2):316–324. doi:10.4103/0970-0358.101309. Link: https://pubmed.ncbi.nlm.nih.gov/23162231/
Hou S, Wu G, Liang J, et al. "Hyperbaric oxygen on rehabilitation of brain tumors after surgery and effects on TNF-α and IL-6 levels." Oncology Letters. 2019;17(3):3277–3282. doi:10.3892/ol.2019.10000.
Perren S, Gatt A, Papanas N, et al. "Hyperbaric oxygen therapy in ischemic foot ulcers in type 2 diabetes: a clinical trial." Open Cardiovascular Medicine Journal. 2018;12:80–85. Published 2018 Aug 31. doi:10.2174/1874192401812010080.
Eskes AM, Ubbink DT, Lubbers MJ, et al. "Hyperbaric oxygen therapy: solution for difficult-to-heal acute wounds? Systematic review." World Journal of Surgery. 2011;35(3):535–542. doi:10.1007/s00268-010-0923-4.
Link: https://link.springer.com/article/10.1007/s00268-010-0923-4
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Boussi-Gross R, Golan H, Fishlev G, et al. "Hyperbaric oxygen therapy can improve post-concussion syndrome years after mild traumatic brain injury – randomized prospective trial." PLoS One. 2013;8(11):e79995. Published 2013 Nov 15. doi:10.1371/journal.pone.0079995.
Link: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0079995
Tal S, Hadanny A, Sasson E, et al. "Hyperbaric oxygen therapy can induce angiogenesis and regeneration of nerve fibers in traumatic brain injury patients." Frontiers in Human Neuroscience. 2017;11:508. Published 2017 Oct 19. doi:10.3389/fnhum.2017.00508.
Link: https://www.frontiersin.org/articles/10.3389/fnhum.2017.00508/full
Meng XE, Zhang Y, Li N, et al. "Hyperbaric oxygen alleviates secondary brain injury after trauma through inhibition of TLR4/NF-κB signaling pathway." Medical Science Monitor. 2016;22:284–288. Published 2016 Jan 26. doi:10.12659/msm.894148.
Vlodavsky E, Palzur M, Feinsod M, et al. "Evaluation of the apoptosis-related proteins of the BCL-2 family in the traumatic penumbra area of the rat model of cerebral contusion, managed by hyperbaric oxygen therapy: a quantitative immunohistochemical study." Acta Neuropathologica. 2005;110(2):120-126.
Hadanny A, Abbott S, Suzin G, et al. "Effect of hyperbaric oxygen therapy on chronic neurocognitive deficits of post-traumatic brain injury patients: retrospective analysis." BMJ Open. 2018;8(9):e023387. Published 2018 Sep 28. doi:10.1136/bmjopen-2018-023387.
Dong Y, Hu XH, Wu T, et al. "Effect of hyperbaric oxygenation therapy on post-concussion syndrome." Experimental and Therapeutic Medicine. 2018;16(3):2193–2202. doi:10.3892/etm.2018.6463.
Tsutsumi I, Tsujimoto Y, Takahashi S, et al. "Hyperbaric oxygen therapy for persistent post-concussion syndrome following mild traumatic brain injury." Cochrane Database of Systematic Reviews. 2017;2017(7):CD012727. doi:10.1002/14651858.CD012727.
Link: https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD012727/full
Eve DJ, Steele MR, Sanberg PR, et al. "Hyperbaric oxygen therapy as a potential treatment for post-traumatic stress disorder associated with traumatic brain injury." Neuropsychiatric Disease and Treatment. 2016;12:2689–2705. doi:10.2147/NDT.S110126.
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Rosario ER, Kaplan SE, Khonsari S, et al. "The effect of hyperbaric oxygen therapy on functional impairments caused by ischemic stroke." Neurology Research International. 2018;2018:3172679. doi:10.1155/2018/3172679.
Link: https://onlinelibrary.wiley.com/doi/10.1155/2018/3172679
Ostrowski RP, Stepien K, Pucko E, et al. "The efficacy of hyperbaric oxygen in hemorrhagic stroke: experimental and clinical implications." Archives of Medical Science. 2017;13(5):1217–1223. doi:10.5114/aoms.2017.65081.
Efrati S, Fishlev G, Bechor Y, et al. "Hyperbaric oxygen induces late neuroplasticity in post-stroke patients–randomized, prospective trial." PLoS One. 2013;8(1):e53716. doi:10.1371/journal.pone.0053716.
Link: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0053716
Liska GM, Lippert T, Russo E, et al. "A dual role for hyperbaric oxygen in stroke neuroprotection: preconditioning of the brain and stem cells." Conditioning Medicine. 2018;1(4):151–166.
Hadanny A, Efrati S. "Oxygen–a limiting factor for brain recovery." Critical Care. 2015;19(1):307. doi:10.1186/s13054-015-1034-2.
Link: https://ccforum.biomedcentral.com/articles/10.1186/s13054-015-1034-2
Hadanny A, Golan H, Fishlev G, et al. "Hyperbaric oxygen can induce neuroplasticity and improve cognitive functions of patients suffering from anoxic brain damage." Restorative Neurology and Neuroscience. 2015;33(4):471–486. doi:10.3233/RNN-150517.
Link: https://content.iospress.com/articles/restorative-neurology-and-neuroscience/rnn150517
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Eve DJ, Steele MR, Sanberg PR, et al. "Hyperbaric oxygen therapy as a potential treatment for post-traumatic stress disorder associated with traumatic brain injury." Neuropsychiatric Disease and Treatment. 2016;12:2689–2705. doi:10.2147/NDT.S110126.
Harch PG, Andrews SR, Fogarty EF, et al. "Case control study: hyperbaric oxygen treatment of mild traumatic brain injury persistent post-concussion syndrome and post-traumatic stress disorder." Medical Gas Research. 2017;7(3):156–174. doi:10.4103/2045-9912.215745.
He H, Li X, He Y. "Hyperbaric oxygen therapy attenuates neuronal apoptosis induced by traumatic brain injury via Akt/GSK3β/β-catenin pathway." Neuropsychiatric Disease and Treatment. 2019;15:369–374. doi:10.2147/NDT.S183632.
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Nazario J, Kuffler DP. "Hyperbaric oxygen therapy and promoting neurological recovery following nerve trauma." Undersea and Hyperbaric Medicine. 2011;38(5):345–366.
Hu Q, Manaenko A, Xu T, et al. "Hyperbaric oxygen therapy for traumatic brain injury: bench-to-bedside." Medical Gas Research. 2016;6(2):102–110. Published 2016 Jul 11. doi:10.4103/2045-9912.184720.
Kiralp MZ, Yildiz Ş, Vural D, et al. "Effectiveness of hyperbaric oxygen therapy in the treatment of complex regional pain syndrome." Journal of International Medical Research. 2004;32(3):258–262.
Link: https://journals.sagepub.com/doi/10.1177/147323000403200304
Oroglu B, Turker T, Aktas S, et al. "Effect of hyperbaric oxygen therapy on tensile repair of the peripheral nerves." Undersea and Hyperbaric Medicine. 2011;38(5):367–373.
Vadas D, Kalichman L, Hadanny A, et al. "Hyperbaric oxygen environment can enhance brain activity and multitasking performance." Frontiers in Integrative Neuroscience. 2017;11:25. doi:10.3389/fnint.2017.00025.
Link: https://www.frontiersin.org/articles/10.3389/fnint.2017.00025/full
Hadanny A, Maliar A, Fishlev G, et al. "Reversibility of retinal ischemia due to central retinal artery occlusion by hyperbaric oxygen." Clinical Ophthalmology. 2016;11:115–125. doi:10.2147/OPTH.S121307.
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Meng XE, Zhang Y, Li N, et al. "Hyperbaric oxygen alleviates secondary brain injury after trauma through inhibition of TLR4/NF-κB signaling pathway." Medical Science Monitor. 2016;22:284–288. doi:10.12659/msm.894148.
Link: https://pmc.ncbi.nlm.nih.gov/articles/PMC4734681/Dulai PS, Gleeson MW, Taylor D, et al. "Systematic review: the safety and efficacy of hyperbaric oxygen therapy for inflammatory bowel disease." Alimentary Pharmacology & Therapeutics. 2014;39(12):1266–1275. doi:10.1111/apt.12753.
Link: https://onlinelibrary.wiley.com/doi/10.1111/apt.12753Hui J, Zhang ZJ, Zhang X, et al. "Repetitive hyperbaric oxygen treatment attenuates complete Freund’s adjuvant-induced pain and reduces glia-mediated neuroinflammation in the spinal cord." Journal of Pain. 2013;14(7):747–758.
Link: https://pmc.ncbi.nlm.nih.gov/articles/PMC6121430/Li F, Fang L, Huang S, et al. "Hyperbaric oxygenation therapy alleviates chronic constrictive injury-induced neuropathic pain and reduces tumor necrosis factor-alpha production." Anesthesia & Analgesia. 2011;113(3):626–633.
Link: https://pubmed.ncbi.nlm.nih.gov/21596875/Choudhury R. "Hypoxia and hyperbaric oxygen therapy: a review." International Journal of General Medicine. 2018;11:431–442. doi:10.2147/IJGM.S172460.
Link: https://pmc.ncbi.nlm.nih.gov/articles/PMC6251354/
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Dave KR, Prado R, Busto R, et al. "Hyperbaric oxygen therapy protects against mitochondrial dysfunction and delays onset of motor neuron disease in wobbler mice." Neuroscience. 2003;120(1):113–120. doi:10.1016/S0306-4522(03)00244-6.
Link: https://www.sciencedirect.com/science/article/abs/pii/S0306452203002446
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Nyabanga CT, Kulkarni G, Shen B. "Hyperbaric oxygen therapy for chronic antibiotic-refractory ischemic pouchitis." Gastroenterology Report. 2017;5(4):320–321. doi:10.1093/gastro/gov038.
Link: https://academic.oup.com/gastro/article/5/4/320/3073986